Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.
Function
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.
Interactions
Interleukin 5 receptor alpha subunit has been shown to interact with:
- Interleukin 5,
- Janus kinase 2,
- Protein unc-119 homolog, and
- SDCBP
See also
- Cluster of differentiation
- Benralizumab
- Mepolizumab
- Reslizumab
References
Further reading
External links
- IL5RA protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q01344 (Interleukin-5 receptor subunit alpha) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
